Narrow-band (TL-01) ultraviolet B phototherapy for chronic plaque psoriasis: three times or five times weekly treatment?
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Three and five times weekly narrow-band TL-01 (311-313 nm) ultraviolet (UV) B phototherapy regimens for chronic plaque psoriasis were compared in a randomized, observer-blinded, half-body, within-patient paired study.

Twenty-one patients entered the study, Sixteen reached clearance or minimal residual activity on both sides. Of the other five, three withdrew because they did not reach clearance on the 5 x weekly side by a maximum of 30 treatments, one when he was satisfied with moderate improvement and one because of repeated failure to attend.

Those who completed treatment reached clearance or minimal residual activity after a median of 35 days with 5 x weekly treatment compared with 40 days with 3 x weekly treatment.

Fifteen (of 16) developed at least one episode of well-demarcated erythema during 5x weekly treatment compared with just three of 16 treated 3x weekly.

There was no significant difference between regimens in duration of remission, For this skin phototype I-III population, the more rapid clearance of psoriasis with 5x weekly phototherapy is not, for the majority of patients, sufficient to justify the extra exposures and higher UVB dose.

We no longer use 5 x weekly phototherapy for psoriasis

Dawe RS, Wainwright NJ, Cameron H, Ferguson J BRITISH JOURNAL OF DERMATOLOGY 138: (5) 833-839 MAY 1998

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